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KMID : 0624620100430100698
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BMB Reports
2010 Volume.43 No. 10 p.698 ~ p.703
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Susceptibility for breast cancer in young patients with short rare minisatellite alleles of BORIS
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Yoon Se-Lyun
Kim Dae-Cheol
Cho Se-Heon
Lee Sang-Yeop
Chu In-Sun
Heo Jeong-Hoon
Leem Sun-Hee
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Abstract
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In this study, we characterized two blocks of minisatellites in the 5' upstream region of the BORIS gene (BORIS-MS1, -MS2). BORIS-MS2 was found to be polymorphic; therefore, this locus could be useful as a marker for DNA fingerprinting. We assessed the association between BORIS-MS2 and breast cancer by a case-control study with 428 controls and 793 breast cancers cases. Rare alleles in the younger group (age, <40) were associated with a statistically significant increased risk of breast cancer (odds ratio, 4.84; 95% confidence interval, 1.06-22.22; and P = 0.026). A statistically significant association between the short rare alleles and cancer was identified in the younger group (8.02; 1.01-63.83; P = 0.021). Kaplan-Meier estimates showed that poor prognosis was associated with patients who contained the rare alleles. Our data suggest that the short rare alleles of BORIS-MS2 could be used to identify the risk for breast cancer in young patients.
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KEYWORD
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BORIS, Breast cancer, Case-control study, Minisatellite polymorphisms, VNTR
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